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Adjust the dosage to obtain an appropriate balance between management of pain and opioid-related adverse reactions.When a patient who has been taking Demerol Injection regularly and may be physically dependent no longer requires therapy with Demerol Injection, taper the dose gradually, by 25% to 50% every 2 to 4 days, while monitoring carefully for signs and symptoms of withdrawal.Injectable, Uni-Amp unit dose pak-ampuls: 25 mg/0.5 m L, 50 mg/m L, 75 mg/1.5 m L, 100 mg/2 m L, and 100 mg/m L Injectable, multiple-dose vials: 1500 mg/30 m L (50 mg/m L) and 2000 mg/20 m L (100 mg/m L), containing 0.1% metacresol as a preservative.Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed Demerol Injection.

seizures) from the accumulation of the meperidine metabolite, normeperidine.The dose of Demerol Injection should be proportionately reduced (usually by 25 to 50 percent) when administered concomitantly with phenothiazines and many other tranquilizers since they potentiate the action of Demerol Injection.Injectable, Carpuject Single-dose cartridge with Luer Lock for the Carpuject Syringe System: 25 mg/m L, 50 mg/m L, 75 mg/m L, and 100 mg/m L.In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in meperidine plasma concentration.Monitor patients receiving Demerol Injection and any CYP3A4 inhibitor or inducer [Concomitant use of Demerol Injection with monoamine oxidase (MAO) inhibitors can result in coma, severe respiratory depression, cyanosis, and hypotension.WARNING: ADDICTION, ABUSE, AND MISUSE; LIFE-THREATENING RESPIRATORY DEPRESSION; NEONATAL OPIOID WITHDRAWAL SYNDROME; CYTOCHROME P450 3A4 INTERACTION; RISKS FROM CONCOMITANT USE WITH BENZODIAZEPINES OR OTHER CNS DEPRESSANTS; and MONOAMINE OXIDASE (MOA) INHIBITORS INTERACTIONSDemerol Injection exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death.