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BRCA1 plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability.BRCA1 forms several distinct complexes through association with different adaptor proteins, and each complex forms in a mutually exclusive manner (19261749, images] [Full Text]" pmid="19261749"Miki et al.

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Unlike full-length BRCA1, BRCA1-IRIS was exclusively chromatin associated, failed to interact with BARD1 in vivo or in vitro, exhibited unique nuclear immunostaining, and coimmunoprecipitated with core DNA replication initiation sites and with replication initiation proteins.

Suppression of BRCA1-IRIS hindered DNA replication, whereas overexpression stimulated DNA replication. (1996) determined the detailed structure of the BRCA1 genomic region.

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